Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

N‐Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)‐catalysed demethylation of N (ε)‐methylated lysine 26 on histone 1 isotype 4 (H1.4). The results reveal that methylated H1....

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Udgivet i:FEBS Lett
Main Authors: Walport, Louise J., Hopkinson, Richard J., Chowdhury, Rasheduzzaman, Zhang, Yijia, Bonnici, Joanna, Schiller, Rachel, Kawamura, Akane, Schofield, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Letters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220849/
https://ncbi.nlm.nih.gov/pubmed/30156264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13231
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