Targeting histone lysine demethylases — Progress, challenges, and the future()

Por Thinnes, Cyrille C., England, Katherine S., Kawamura, Akane, Chowdhury, Rasheduzzaman, Schofield, Christopher J., Hopkinson, Richard J.
Publicado no Biochim Biophys Acta Gene Regul Mech (2014)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

Por Walport, Louise J., Hopkinson, Richard J., Chowdhury, Rasheduzzaman, Schiller, Rachel, Ge, Wei, Kawamura, Akane, Schofield, Christopher J.
Publicado no Nat Commun (2016)

Diagnosis for COVID-19: current status and future prospects

Por Kabir, MD Alamgir, Ahmed, Rajib, Iqbal, Sheikh Muhammad Asher, Chowdhury, Rasheduzzaman, Paulmurugan, Ramasamy, Demirci, Utkan, Asghar, Waseem
Publicado no Expert Rev Mol Diagn (2021)

Management of COVID-19: current status and future prospects

Por Kabir, Md Alamgir, Ahmed, Rajib, Chowdhury, Rasheduzzaman, Iqbal, Sheikh Muhammad Asher, Paulmurugan, Ramasamy, Demirci, Utkan, Asghar, Waseem
Publicado no Microbes Infect (2021)

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

Por Williams, Sophie T, Walport, Louise J, Hopkinson, Richard J, Madden, Sarah K, Chowdhury, Rasheduzzaman, Schofield, Christopher J, Kawamura, Akane
Publicado no Epigenetics (2015)

Modulating carnitine levels by targeting its biosynthesis pathway – selective inhibition of γ-butyrobetaine hydroxylase

Por Rydzik, Anna M., Chowdhury, Rasheduzzaman, Kochan, Grazyna T., Williams, Sophie T., McDonough, Michael A., Kawamura, Akane, Schofield, Christopher J.
Publicado no Chem Sci (2014)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

Por Islam, Md. Saiful, McDonough, Michael A., Chowdhury, Rasheduzzaman, Gault, Joseph, Khan, Amjad, Pires, Elisabete, Schofield, Christopher J.
Publicado no J Biol Chem (2019)

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

Por Hewitson, Kirsty S., Holmes, Samantha L., Ehrismann, Dominic, Hardy, Adam P., Chowdhury, Rasheduzzaman, Schofield, Christopher J., McDonough, Michael A.
Publicado em 2008

Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

Por Walport, Louise J., Hopkinson, Richard J., Chowdhury, Rasheduzzaman, Zhang, Yijia, Bonnici, Joanna, Schiller, Rachel, Kawamura, Akane, Schofield, Christopher J.
Publicado no FEBS Lett (2018)

Human Oxygenase Variants Employing a Single Protein Fe(II) Ligand Are Catalytically Active

Por Brasnett, Amelia, Pfeffer, Inga, Brewitz, Lennart, Chowdhury, Rasheduzzaman, Nakashima, Yu, Tumber, Anthony, McDonough, Michael A., Schofield, Christopher J.
Publicado no Angew Chem Int Ed Engl (2021)

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

Por Lippl, Kerstin, Boleininger, Anna, McDonough, Michael A, Abboud, Martine I, Tarhonskaya, Hanna, Chowdhury, Rasheduzzaman, Loenarz, Christoph, Schofield, Christopher J
Publicado no Hypoxia (Auckl) (2018)

JMJD5 is a human arginyl C-3 hydroxylase

Por Wilkins, Sarah E., Islam, Md. Saiful, Gannon, Joan M., Markolovic, Suzana, Hopkinson, Richard J., Ge, Wei, Schofield, Christopher J., Chowdhury, Rasheduzzaman
Publicado no Nat Commun (2018)

Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase

Por Wilkins, Sarah E., Islam, Md. Saiful, Gannon, Joan M., Markolovic, Suzana, Hopkinson, Richard J., Ge, Wei, Schofield, Christopher J., Chowdhury, Rasheduzzaman
Publicado no Nat Commun (2018)

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2

Por Chowdhury, Rasheduzzaman, Abboud, Martine I., McAllister, Tom E., Banerji, Biswadip, Bhushan, Bhaskar, Sorensen, John L., Kawamura, Akane, Schofield, Christopher J.
Publicado no Sci Rep (2020)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

Por Holt-Martyn, James P., Tumber, Anthony, Rahman, Mohammed Z., Lippl, Kerstin, Figg, William, McDonough, Michael A., Chowdhury, Rasheduzzaman, Schofield, Christopher J.
Publicado no Medchemcomm (2019)

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture

Por Bush, Jacob T., Leśniak, Robert K., Yeh, Tzu-Lan, Belle, Roman, Kramer, Holger, Tumber, Anthony, Chowdhury, Rasheduzzaman, Flashman, Emily, Mecinović, Jasmin, Schofield, Christopher J.
Publicado no Chem Commun (Camb) (2019)

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

Por Yang, Ming, Chowdhury, Rasheduzzaman, Ge, Wei, Hamed, Refaat B, McDonough, Michael A, Claridge, Timothy D W, Kessler, Benedikt M, Cockman, Matthew E, Ratcliffe, Peter J, Schofield, Christopher J
Publicado em 2011

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

Por Liu, Tongri, Abboud, Martine I., Chowdhury, Rasheduzzaman, Tumber, Anthony, Hardy, Adam P., Lippl, Kerstin, Lohans, Christopher T., Pires, Elisabete, Wickens, James, McDonough, Michael A., West, Christopher M., Schofield, Christopher J.
Publicado no J Biol Chem (2021)

The role of PHD2 mutations in the pathogenesis of erythrocytosis

Por Gardie, Betty, Percy, Melanie J, Hoogewijs, David, Chowdhury, Rasheduzzaman, Bento, Celeste, Arsenault, Patrick R, Richard, Stéphane, Almeida, Helena, Ewing, Joanne, Lambert, Frédéric, McMullin, Mary Frances, Schofield, Christopher J, Lee, Frank S
Publicado no Hypoxia (Auckl) (2014)

Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

Por Yang, Ming, Ge, Wei, Chowdhury, Rasheduzzaman, Claridge, Timothy D. W., Kramer, Holger B., Schmierer, Bernhard, McDonough, Michael A., Gong, Lingzhi, Kessler, Benedikt M., Ratcliffe, Peter J., Coleman, Mathew L., Schofield, Christopher J.
Publicado em 2011