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Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
We describe covalently binding modulators of the activity of human prolyl hydroxylase domain 2 (PHD2) and studies towards a strategy for photocapture of PHD2 substrates. Reversible active site binding of electrophile bearing compounds enables susbsequent covalent reaction with a lysine residue (K408...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6350621/ https://ncbi.nlm.nih.gov/pubmed/30452037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc07706a |
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