2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

Prolyl hydroxylation of hypoxia inducible factor (HIF)-α, as catalysed by the Fe(ii)/2-oxoglutarate (2OG)-dependent prolyl hydroxylase domain (PHD) enzymes, has a hypoxia sensing role in animals. We report that binding of prolyl-hydroxylated HIF-α to PHD2 is ∼50 fold hindered by prior 2OG binding; t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Commun (Camb)
Prif Awduron: Abboud, Martine I., McAllister, Tom E., Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Jorgensen, Christian, Domene, Carmen, Mecinović, Jasmin, Lippl, Kerstin, Hancock, Rebecca L., Hopkinson, Richard J., Kawamura, Akane, Claridge, Timothy D. W., Schofield, Christopher J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2018
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885369/
https://ncbi.nlm.nih.gov/pubmed/29522057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc00387d
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