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Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
The 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are targets for treatment of anaemia and other ischaemia related diseases. PHD inhibitors are in clinical trials; however, the number of reported templates for PHD inhibition is limited. We report structure–...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6482412/ https://ncbi.nlm.nih.gov/pubmed/31057728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00548f |
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