Wird geladen...

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ChemMedChem
Hauptverfasser: Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, Tumber, Anthony, Yeh, Tzu‐Lan, Abboud, Martine I., Lippl, Kerstin, Lohans, Christopher T., Langley, Gareth W., Figg, William, McDonough, Michael A., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496690/
https://ncbi.nlm.nih.gov/pubmed/31751494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900557
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!