Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templat...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:ChemMedChem
Main Authors: Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, Tumber, Anthony, Yeh, Tzu‐Lan, Abboud, Martine I., Lippl, Kerstin, Lohans, Christopher T., Langley, Gareth W., Figg, William, McDonough, Michael A., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496690/
https://ncbi.nlm.nih.gov/pubmed/31751494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900557
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