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Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templat...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, Tumber, Anthony, Yeh, Tzu‐Lan, Abboud, Martine I., Lippl, Kerstin, Lohans, Christopher T., Langley, Gareth W., Figg, William, McDonough, Michael A., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496690/
https://ncbi.nlm.nih.gov/pubmed/31751494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900557
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