Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe cellular, biophysical, and biochemical studies comparing four PHD i...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Yeh, Tzu-Lan, Leissing, Thomas M., Abboud, Martine I., Thinnes, Cyrille C., Atasoylu, Onur, Holt-Martyn, James P., Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T., Leung, Ivanhoe K. H., Morcrette, Helen, Clifton, Ian J., Claridge, Timothy D. W., Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J., Chowdhury, Rasheduzzaman, Pugh, Christopher W., Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802278/
https://ncbi.nlm.nih.gov/pubmed/29435217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02103h
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