Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on non HIF substrates. To gain insight into the factors...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Liu, Tongri, Abboud, Martine I., Chowdhury, Rasheduzzaman, Tumber, Anthony, Hardy, Adam P., Lippl, Kerstin, Lohans, Christopher T., Pires, Elisabete, Wickens, James, McDonough, Michael A., West, Christopher M., Schofield, Christopher J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864055/
https://ncbi.nlm.nih.gov/pubmed/32934009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013998
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