Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe cellular, biophysical, and biochemical studies comparing four PHD i...

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書誌詳細
出版年:Chem Sci
主要な著者: Yeh, Tzu-Lan, Leissing, Thomas M., Abboud, Martine I., Thinnes, Cyrille C., Atasoylu, Onur, Holt-Martyn, James P., Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T., Leung, Ivanhoe K. H., Morcrette, Helen, Clifton, Ian J., Claridge, Timothy D. W., Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J., Chowdhury, Rasheduzzaman, Pugh, Christopher W., Schofield, Christopher J.
フォーマット: Artigo
言語:Inglês
出版事項: Royal Society of Chemistry 2017
主題:
Chemistry
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802278/
https://ncbi.nlm.nih.gov/pubmed/29435217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02103h
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