Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

A 2-His-1-carboxylate triad of iron binding residues is present in many non-heme iron oxygenases including the Fe(II) and 2-oxoglutarate (2OG)-dependent dioxygenases. Three variants (D201A, D201E, and D201G) of the iron binding Asp-201 residue of an asparaginyl hydroxylase, factor inhibiting HIF (FI...

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Autori principali: Hewitson, Kirsty S., Holmes, Samantha L., Ehrismann, Dominic, Hardy, Adam P., Chowdhury, Rasheduzzaman, Schofield, Christopher J., McDonough, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Enzyme Catalysis and Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258853/
https://ncbi.nlm.nih.gov/pubmed/18611856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804999200
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