Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

HIF (hypoxia-inducible factor) is an αβ transcription factor that modulates the hypoxic response in many animals. The cellular abundance and activity of HIF-α are regulated by its post-translational hydroxylation. The hydroxylation of HIF is catalysed by PHD (prolyl hydroxylase domain) enzymes and F...

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Detalhes bibliográficos
Main Authors: Lancaster, David E., McNeill, Luke A., McDONOUGH, Michael A., Aplin, Robin T., Hewitson, Kirsty S., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133735/
https://ncbi.nlm.nih.gov/pubmed/15239670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040735
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