New horizons in hypoxia signaling pathways

Por Pugh, Christopher W., Ratcliffe, Peter J.
Publicado no Exp Cell Res (2017)

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice

Por Milkiewicz, Malgorzata, Pugh, Christopher W, Egginton, Stuart
Publicado em 2004

Hypoxia and oxidative stress in breast cancer: Hypoxia signalling pathways

Por Pugh, Christopher W, Gleadle, Jonathan, Maxwell, Patrick H
Publicado em 2001

The relationship between symptoms and blood pressure during maintenance hemodialysis

Por Meredith, David J, Pugh, Christopher W, Sutherland, Sheera, Tarassenko, Lionel, Birks, Jacqueline
Publicado no Hemodial Int (2015)

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

Por Masson, Norma, Willam, Carsten, Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.
Publicado em 2001

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Por Schödel, Johannes, Oikonomopoulos, Spyros, Ragoussis, Jiannis, Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.
Publicado em 2011

Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors: NEW LINK BETWEEN HYPOXIA SIGNALING AND IRON HOMEOSTASIS

Por Lakhal, Samira, Schödel, Johannes, Townsend, Alain R. M., Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.
Publicado em 2011

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Por Talks, Katherine L., Turley, Helen, Gatter, Kevin C., Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J., Harris, Adrian L.
Publicado em 2000

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

Por Chen, Ruo-Li, Nagel, Simon, Papadakis, Michalis, Bishop, Tammie, Pollard, Patrick, Ratcliffe, Peter J, Pugh, Christopher W, Buchan, Alastair M
Publicado em 2012

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

Por Lancaster, David E., McNeill, Luke A., McDONOUGH, Michael A., Aplin, Robin T., Hewitson, Kirsty S., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado em 2004

Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis

Por Willam, Carsten, Masson, Norma, Tian, Ya-Min, Mahmood, S. Aleema, Wilson, Michael I., Bicknell, Roy, Eckardt, Kai-Uwe, Maxwell, Patrick H., Ratcliffe, Peter J., Pugh, Christopher W.
Publicado em 2002

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

Por Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.
Publicado no J Biol Chem (2016)

Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans

Por Bishop, Tammie, Lau, Kah Weng, Epstein, Andrew C. R, Kim, Stuart K, Jiang, Min, O'Rourke, Delia, Pugh, Christopher W, Gleadle, Jonathan M, Taylor, Martin S, Hodgkin, Jonathan, Ratcliffe, Peter J
Publicado em 2004

Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

Por Raval, Raju R., Lau, Kah Weng, Tran, Maxine G. B., Sowter, Heidi M., Mandriota, Stefano J., Li, Ji-Liang, Pugh, Christopher W., Maxwell, Patrick H., Harris, Adrian L., Ratcliffe, Peter J.
Publicado em 2005

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

Por Tian, Ya-Min, Yeoh, Kar Kheng, Lee, Myung Kyu, Eriksson, Tuula, Kessler, Benedikt M., Kramer, Holger B., Edelmann, Mariola J., Willam, Carsten, Pugh, Christopher W., Schofield, Christopher J., Ratcliffe, Peter J.
Publicado em 2011

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway

Por Hodson, Emma J., Nicholls, Lynn G., Turner, Philip J., Llyr, Ronan, Fielding, James W., Douglas, Gillian, Ratnayaka, Indrika, Robbins, Peter A., Pugh, Christopher W., Buckler, Keith J., Ratcliffe, Peter J., Bishop, Tammie
Publicado no J Physiol (2015)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Por Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.
Publicado no Nat Commun (2016)

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

Por O'Flaherty, Linda, Adam, Julie, Heather, Lisa C., Zhdanov, Alexander V., Chung, Yuen-Li, Miranda, Melroy X., Croft, Joanne, Olpin, Simon, Clarke, Kieran, Pugh, Christopher W., Griffiths, John, Papkovsky, Dmitri, Ashrafian, Houman, Ratcliffe, Peter J., Pollard, Patrick J.
Publicado em 2010

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

Por Bishop, Tammie, Talbot, Nick P, Turner, Philip J, Nicholls, Lynn G, Pascual, Alberto, Hodson, Emma J, Douglas, Gillian, Fielding, James W, Smith, Thomas G, Demetriades, Marina, Schofield, Christopher J, Robbins, Peter A, Pugh, Christopher W, Buckler, Keith J, Ratcliffe, Peter J
Publicado em 2013

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Por Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.
Publicado em 2006