Novel Insights into FH-associated Disease are KEAPing the Lid on Oncogenic HIF Signalling

Por Adam, Julie, Ratcliffe, Peter J., Pollard, Patrick J.
Publicado em 2011

Cultural interventions through children's literature and arts-based practices in times of disaster: A case study of reading mediators' response to the Mexican earthquakes (Septembe...

Por Hirsu, Lavinia, Arizpe, Evelyn, McAdam, Julie E.
Publicado no Int J Disaster Risk Reduct (2020)

The emerging role of fumarate as an oncometabolite

Por Yang, Ming, Soga, Tomoyoshi, Pollard, Patrick J., Adam, Julie
Publicado em 2012

Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression

Por McCarthy, Michael T., Lin, Da, Soga, Tomoyoshi, Adam, Julie, O'Callaghan, Christopher A.
Publicado no Eur J Immunol (2019)

The Succinated Proteome of FH-Mutant Tumours

Por Yang, Ming, Ternette, Nicola, Su, Huizhong, Dabiri, Raliat, Kessler, Benedikt M., Adam, Julie, Teh, Bin Tean, Pollard, Patrick J.
Publicado em 2014

Purine nucleotide metabolism regulates expression of the human immune ligand MICA

Por McCarthy, Michael T., Moncayo, Gerard, Hiron, Thomas K., Jakobsen, Niels A., Valli, Alessandro, Soga, Tomoyoshi, Adam, Julie, O'Callaghan, Christopher A.
Publicado no J Biol Chem (2018)

Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism

Por Bardella, Chiara, Olivero, Martina, Lorenzato, Annalisa, Geuna, Massimo, Adam, Julie, O'Flaherty, Linda, Rustin, Pierre, Tomlinson, Ian, Pollard, Patrick J., Di Renzo, Maria Flavia
Publicado em 2012

Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes

Por Manuel, Allison M., Walla, Michael D., Faccenda, Adam, Martin, Stephanie L., Tanis, Ross M., Piroli, Gerardo G., Adam, Julie, Kantor, Boris, Mutus, Bulent, Townsend, Danyelle M., Frizzell, Norma
Publicado no Antioxid Redox Signal (2017)

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Por Knudsen, Jakob G., Hamilton, Alexander, Ramracheya, Reshma, Tarasov, Andrei I., Brereton, Melissa, Haythorne, Elizabeth, Chibalina, Margarita V., Spégel, Peter, Mulder, Hindrik, Zhang, Quan, Ashcroft, Frances M., Adam, Julie, Rorsman, Patrik
Publicado no Cell Metab (2019)

Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)

Por Thalhammer, Armin, Bencokova, Zuzana, Poole, Rachel, Loenarz, Christoph, Adam, Julie, O'Flaherty, Linda, Schödel, Johannes, Mole, David, Giaslakiotis, Konstantinos, Schofield, Christopher J., Hammond, Ester M., Ratcliffe, Peter J., Pollard, Patrick J.
Publicado em 2011

PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies

Por Fielding, James W., Hodson, Emma J., Cheng, Xiaotong, Ferguson, David J. P., Eckardt, Luise, Adam, Julie, Lip, Philomena, Maton‐Howarth, Matthew, Ratnayaka, Indrika, Pugh, Christopher W., Buckler, Keith J., Ratcliffe, Peter J., Bishop, Tammie
Publicado no J Physiol (2018)

Increased expression of the diabetes gene SOX4 reduces insulin secretion by impaired fusion pore expansion

Por Collins, Stephan C., Do, Hyun Woong, Hastoy, Benoit, Hugill, Alison, Adam, Julie, Chibalina, Margarita V., Galvanovskis, Juris, Godazgar, Mahdieh, Lee, Sheena, Goldsworthy, Michelle, Salehi, Albert, Tarasov, Andrei I., Rosengren, Anders H., Cox, Roger, Rorsman, Patrik
Publicado no Diabetes (2016)

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

Por Ternette, Nicola, Yang, Ming, Laroyia, Mahima, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Wolhulter, Kathryn, Igarashi, Kaori, Saito, Kaori, Kato, Keiko, Fischer, Roman, Berquand, Alexandre, Kessler, Benedikt M., Lappin, Terry, Frizzell, Norma, Soga, Tomoyoshi, Adam, Julie, Pollard, Patrick J.
Publicado em 2013

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

Por O'Flaherty, Linda, Adam, Julie, Heather, Lisa C., Zhdanov, Alexander V., Chung, Yuen-Li, Miranda, Melroy X., Croft, Joanne, Olpin, Simon, Clarke, Kieran, Pugh, Christopher W., Griffiths, John, Papkovsky, Dmitri, Ashrafian, Houman, Ratcliffe, Peter J., Pollard, Patrick J.
Publicado em 2010

Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance

Por Nijhuis, Anke, Thompson, Hannah, Adam, Julie, Parker, Alexandra, Gammon, Luke, Lewis, Amy, Bundy, Jacob G., Soga, Tomoyoshi, Jalaly, Aisha, Propper, David, Jeffery, Rosemary, Suraweera, Nirosha, McDonald, Sarah, Thaha, Mohamed A., Feakins, Roger, Lowe, Robert, Bishop, Cleo L., Silver, Andrew
Publicado no Hum Mol Genet (2017)

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

Por Singleton, Rachelle S., Liu-Yi, Phebee, Formenti, Fabio, Ge, Wei, Sekirnik, Rok, Fischer, Roman, Adam, Julie, Pollard, Patrick J., Wolf, Alexander, Thalhammer, Armin, Loenarz, Christoph, Flashman, Emily, Yamamoto, Atsushi, Coleman, Mathew L., Kessler, Benedikt M., Wappner, Pablo, Schofield, Christopher J., Ratcliffe, Peter J., Cockman, Matthew E.
Publicado em 2014

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

Por Adam, Julie, Hatipoglu, Emine, O'Flaherty, Linda, Ternette, Nicola, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Nye, Emma, Stamp, Gordon W., Wolhuter, Kathryn, Stevens, Marcus, Fischer, Roman, Carmeliet, Peter, Maxwell, Patrick H., Pugh, Chris W., Frizzell, Norma, Soga, Tomoyoshi, Kessler, Benedikt M., El-Bahrawy, Mona, Ratcliffe, Peter J., Pollard, Patrick J.
Publicado em 2011

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

Por Adam, Julie, Yang, Ming, Bauerschmidt, Christina, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Maheswaran, Pratheesh, Özkan, Gizem, Sahgal, Natasha, Baban, Dilair, Kato, Keiko, Saito, Kaori, Iino, Keiko, Igarashi, Kaori, Stratford, Michael, Pugh, Christopher, Tennant, Daniel A., Ludwig, Christian, Davies, Benjamin, Ratcliffe, Peter J., El-Bahrawy, Mona, Ashrafian, Houman, Soga, Tomoyoshi, Pollard, Patrick J.
Publicado em 2013

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Por Vergari, Elisa, Knudsen, Jakob G., Ramracheya, Reshma, Salehi, Albert, Zhang, Quan, Adam, Julie, Asterholm, Ingrid Wernstedt, Benrick, Anna, Briant, Linford J. B., Chibalina, Margarita V., Gribble, Fiona M., Hamilton, Alexander, Hastoy, Benoit, Reimann, Frank, Rorsman, Nils J. G., Spiliotis, Ioannis I., Tarasov, Andrei, Wu, Yanling, Ashcroft, Frances M., Rorsman, Patrik
Publicado no Nat Commun (2019)

Somatostatin secretion by Na(+)-dependent Ca(2+)-induced Ca(2+) release in pancreatic delta-cells

Por Vergari, Elisa, Denwood, Geoffrey, Salehi, Albert, Zhang, Quan, Adam, Julie, Alrifaiy, Ahmed, Wernstedt Asterholm, Ingrid, Benrick, Anna, Chibalina, Margarita V., Eliasson, Lena, Guida, Claudia, Hill, Thomas G., Hamilton, Alexander, Ramracheya, Reshma, Reimann, Frank, Rorsman, Nils J. G., Spilliotis, Ioannis, Tarasov, Andrei I., Walker, Jonathan N., Rorsman, Patrik, Briant, Linford J. B.
Publicado no Nat Metab (2020)