Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanis...

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Published in:Nat Commun
Main Authors: Vergari, Elisa, Knudsen, Jakob G., Ramracheya, Reshma, Salehi, Albert, Zhang, Quan, Adam, Julie, Asterholm, Ingrid Wernstedt, Benrick, Anna, Briant, Linford J. B., Chibalina, Margarita V., Gribble, Fiona M., Hamilton, Alexander, Hastoy, Benoit, Reimann, Frank, Rorsman, Nils J. G., Spiliotis, Ioannis I., Tarasov, Andrei, Wu, Yanling, Ashcroft, Frances M., Rorsman, Patrik
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329806/
https://ncbi.nlm.nih.gov/pubmed/30635569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08193-8
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