Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

OBJECTIVES: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). METHODS: Female mice expressing the Ca(2+) indicator GCaMP3 specifically in alpha-cells were f...

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Publicado no:Mol Metab
Main Authors: Kellard, Joely A., Rorsman, Nils J.G., Hill, Thomas G., Armour, Sarah L., van de Bunt, Martijn, Rorsman, Patrik, Knudsen, Jakob G., Briant, Linford J.B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322681/
https://ncbi.nlm.nih.gov/pubmed/32446876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101021
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