CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets

Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrat...

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Publicat a:Cell Rep
Autors principals: Briant, Linford J.B., Dodd, Michael S., Chibalina, Margarita V., Rorsman, Nils J.G., Johnson, Paul R.V., Carmeliet, Peter, Rorsman, Patrik, Knudsen, Jakob G.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581793/
https://ncbi.nlm.nih.gov/pubmed/29898400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.035
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