Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

OBJECTIVES: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD). METHODS: Female mice expressing the Ca(2+) indicator GCaMP3 specifically in alpha-cells were f...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Metab
Egile Nagusiak: Kellard, Joely A., Rorsman, Nils J.G., Hill, Thomas G., Armour, Sarah L., van de Bunt, Martijn, Rorsman, Patrik, Knudsen, Jakob G., Briant, Linford J.B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322681/
https://ncbi.nlm.nih.gov/pubmed/32446876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101021
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak