The Succinated Proteome of FH-Mutant Tumours

Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels, which may act as an oncometabolite through va...

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Bibliografski detalji
Glavni autori: Yang, Ming, Ternette, Nicola, Su, Huizhong, Dabiri, Raliat, Kessler, Benedikt M., Adam, Julie, Teh, Bin Tean, Pollard, Patrick J.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2014
Teme:
Brief Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192685/
https://ncbi.nlm.nih.gov/pubmed/25105836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo4030640
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