The Succinated Proteome of FH-Mutant Tumours

Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels, which may act as an oncometabolite through va...

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Detaylı Bibliyografya
Asıl Yazarlar: Yang, Ming, Ternette, Nicola, Su, Huizhong, Dabiri, Raliat, Kessler, Benedikt M., Adam, Julie, Teh, Bin Tean, Pollard, Patrick J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2014
Konular:
Brief Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192685/
https://ncbi.nlm.nih.gov/pubmed/25105836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo4030640
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