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A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

The identification of mutated metabolic enzymes in hereditary cancer syndromes has established a direct link between metabolic dysregulation and cancer. Mutations in the Krebs cycle enzyme, fumarate hydratase (FH), predispose affected individuals to leiomyomas, renal cysts, and cancers, though the r...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Adam, Julie, Yang, Ming, Bauerschmidt, Christina, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Maheswaran, Pratheesh, Özkan, Gizem, Sahgal, Natasha, Baban, Dilair, Kato, Keiko, Saito, Kaori, Iino, Keiko, Igarashi, Kaori, Stratford, Michael, Pugh, Christopher, Tennant, Daniel A., Ludwig, Christian, Davies, Benjamin, Ratcliffe, Peter J., El-Bahrawy, Mona, Ashrafian, Houman, Soga, Tomoyoshi, Pollard, Patrick J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cell Press 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675675/
https://ncbi.nlm.nih.gov/pubmed/23643539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.006
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