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A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia
The identification of mutated metabolic enzymes in hereditary cancer syndromes has established a direct link between metabolic dysregulation and cancer. Mutations in the Krebs cycle enzyme, fumarate hydratase (FH), predispose affected individuals to leiomyomas, renal cysts, and cancers, though the r...
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| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cell Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675675/ https://ncbi.nlm.nih.gov/pubmed/23643539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.006 |
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