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Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expre...
Shranjeno v:
| izdano v: | Cell Rep |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cell Press
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5637167/ https://ncbi.nlm.nih.gov/pubmed/28954230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.093 |
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