Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expre...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Adam, Julie, Ramracheya, Reshma, Chibalina, Margarita V., Ternette, Nicola, Hamilton, Alexander, Tarasov, Andrei I., Zhang, Quan, Rebelato, Eduardo, Rorsman, Nils J.G., Martín-del-Río, Rafael, Lewis, Amy, Özkan, Gizem, Do, Hyun Woong, Spégel, Peter, Saitoh, Kaori, Kato, Keiko, Igarashi, Kaori, Kessler, Benedikt M., Pugh, Christopher W., Tamarit-Rodriguez, Jorge, Mulder, Hindrik, Clark, Anne, Frizzell, Norma, Soga, Tomoyoshi, Ashcroft, Frances M., Silver, Andrew, Pollard, Patrick J., Rorsman, Patrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637167/
https://ncbi.nlm.nih.gov/pubmed/28954230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.093
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