Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis

Hypoxia-inducible factor-1 (HIF) is a transcription factor central to oxygen homeostasis. It is regulated via its α isoforms. In normoxia they are ubiquitinated by the von Hippel-Lindau E3 ligase complex and destroyed by the proteasome, thereby preventing the formation of an active transcriptional c...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Willam, Carsten, Masson, Norma, Tian, Ya-Min, Mahmood, S. Aleema, Wilson, Michael I., Bicknell, Roy, Eckardt, Kai-Uwe, Maxwell, Patrick H., Ratcliffe, Peter J., Pugh, Christopher W.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2002
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC124930/
https://ncbi.nlm.nih.gov/pubmed/12149454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162119399
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