Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor α subunits (HIF-1α and HIF-2α), leading to constitutive activation of hypoxia pathways in renal cell carcinoma (RCC). Here we report a comparative analysis of the functions o...

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Detalhes bibliográficos
Main Authors: Raval, Raju R., Lau, Kah Weng, Tran, Maxine G. B., Sowter, Heidi M., Mandriota, Stefano J., Li, Ji-Liang, Pugh, Christopher W., Maxwell, Patrick H., Harris, Adrian L., Ratcliffe, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1157001/
https://ncbi.nlm.nih.gov/pubmed/15964822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5675-5686.2005
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