Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

por Ehrismann, Dominic, Flashman, Emily, Genn, David N., Mathioudakis, Nicolas, Hewitson, Kirsty S., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado 2006

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

por McNeill, Luke A, Hewitson, Kirsty S, Claridge, Timothy D, Seibel, Jürgen F, Horsfall, Louise E, Schofield, Christopher J
Publicado 2002

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.

por Elkins, Jonathan M, Clifton, Ian J, Hernández, Helena, Doan, Linh X, Robinson, Carol V, Schofield, Christopher J, Hewitson, Kirsty S
Publicado 2002

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

por Hewitson, Kirsty S., Holmes, Samantha L., Ehrismann, Dominic, Hardy, Adam P., Chowdhury, Rasheduzzaman, Schofield, Christopher J., McDonough, Michael A.
Publicado 2008

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

por Lancaster, David E., McNeill, Luke A., McDONOUGH, Michael A., Aplin, Robin T., Hewitson, Kirsty S., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado 2004

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

por Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.
Publicado en Nat Commun (2019)

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

por Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.
Publicado 2006

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

por McDonough, Michael A., Li, Vivian, Flashman, Emily, Chowdhury, Rasheduzzaman, Mohr, Christopher, Liénard, Benoît M. R., Zondlo, James, Oldham, Neil J., Clifton, Ian J., Lewis, Jeffrey, McNeill, Luke A., Kurzeja, Robert J. M., Hewitson, Kirsty S., Yang, Evelyn, Jordan, Steven, Syed, Rashid S., Schofield, Christopher J.
Publicado 2006

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase

por Gerken, Thomas, Girard, Christophe A., Tung, Yi-Chun Loraine, Webby, Celia J., Saudek, Vladimir, Hewitson, Kirsty S., Yeo, Giles S. H., McDonough, Michael A., Cunliffe, Sharon, McNeill, Luke A., Galvanovskis, Juris, Rorsman, Patrik, Robins, Peter, Prieur, Xavier, Coll, Anthony P., Ma, Marcella, Jovanovic, Zorica, Farooqi, I. Sadaf, Sedgwick, Barbara, Barroso, Inês, Lindahl, Tomas, Ponting, Chris P., Ashcroft, Frances M., O'Rahilly, Stephen, Schofield, Christopher J.
Publicado 2007