C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43

le Jensen, Sacha A., Aspinall, Georgia, Handford, Penny A.
Foilsithe 2014

Assembly assay identifies a critical region of human fibrillin-1 required for 10–12 nm diameter microfibril biogenesis

le Jensen, Sacha A., Atwa, Ondine, Handford, Penny A.
Foilsithe in PLoS One (2021)

A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias

le Jensen, Sacha A., Iqbal, Sarah, Bulsiewicz, Alicja, Handford, Penny A.
Foilsithe in Hum Mol Genet (2015)

Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/LTBP Superfamily of Matrix Proteins

le Jensen, Sacha A., Iqbal, Sarah, Lowe, Edward D., Redfield, Christina, Handford, Penny A.
Foilsithe 2009

(1)H, (13)C and (15)N assignments of the four N-terminal domains of human fibrillin-1

le Yadin, David A., Robertson, Ian B., Jensen, Sacha A., Handford, Penny A., Redfield, Christina
Foilsithe 2012

(1)H, (13)C and (15)N resonance assignments for the fibrillin-1 EGF2-EGF3-hybrid1-cbEGF1 four-domain fragment

le Robertson, Ian B., Osuch, Isabelle, Yadin, David A., Handford, Penny A., Jensen, Sacha A., Redfield, Christina
Foilsithe 2013

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1

le Robertson, Ian B., Dias, Hans F., Osuch, Isabelle H., Lowe, Edward D., Jensen, Sacha A., Redfield, Christina, Handford, Penny A.
Foilsithe in Structure (2017)

Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly

le Yadin, David A., Robertson, Ian B., McNaught-Davis, Joanne, Evans, Paul, Stoddart, David, Handford, Penny A., Jensen, Sacha A., Redfield, Christina
Foilsithe 2013

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion

le Del Cid, Joselyn S., Reed, Nilgun Isik, Molnar, Kathleen, Liu, Sean, Dang, Bobo, Jensen, Sacha A., DeGrado, William, Handford, Penny A., Sheppard, Dean, Sundaram, Aparna B.
Foilsithe in J Biol Chem (2019)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

le Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.
Foilsithe in Nat Commun (2019)