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The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1
Fibrillin-1 (FBN1) mutations associated with Marfan syndrome lead to an increase in transforming growth factor β (TGF-β) activation in connective tissues resulting in pathogenic changes including aortic dilatation and dissection. Since FBN1 binds latent TGF-β binding proteins (LTBPs), the major rese...
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| Pubblicato in: | Structure |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cell Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5548924/ https://ncbi.nlm.nih.gov/pubmed/28669633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.06.003 |
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