Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects

Por Krojer, Tobias, von Delft, Frank
Publicado em 2011

Proper modelling of ligand binding requires an ensemble of bound and unbound states

Por Pearce, Nicholas M., Krojer, Tobias, von Delft, Frank
Publicado no Acta Crystallogr D Struct Biol (2017)

Squeezing the most from every crystal: the fine details of data collection

Por Krojer, Tobias, Pike, Ashley C. W., von Delft, Frank
Publicado em 2013

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

Por Sawa, Justyna, Malet, Hélène, Krojer, Tobias, Canellas, Flavia, Ehrmann, Michael, Clausen, Tim
Publicado em 2011

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase

Por Pfeiffer, Martin, Johansson, Catrine, Krojer, Tobias, Kavanagh, Kathryn L, Oppermann, Udo, Nidetzky, Bernd
Publicado no ACS Catal (2019)

An overview of heavy-atom derivatization of protein crystals

Por Pike, Ashley C. W., Garman, Elspeth F., Krojer, Tobias, von Delft, Frank, Carpenter, Elisabeth P.
Publicado no Acta Crystallogr D Struct Biol (2016)

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

Por Pearce, Nicholas M., Bradley, Anthony R., Krojer, Tobias, Marsden, Brian D., Deane, Charlotte M., von Delft, Frank
Publicado no Struct Dyn (2017)

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

Por Krojer, Tobias, Pangerl, Karen, Kurt, Juliane, Sawa, Justyna, Stingl, Christoph, Mechtler, Karl, Huber, Robert, Ehrmann, Michael, Clausen, Tim
Publicado em 2008

A generic protocol for protein crystal dehydration using the HC1b humidity controller

Por Lobley, Carina M. C., Sandy, James, Sanchez-Weatherby, Juan, Mazzorana, Marco, Krojer, Tobias, Nowak, Radosław P., Sorensen, Thomas L.
Publicado no Acta Crystallogr D Struct Biol (2016)

Regulation of the σE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upo...

Por Hasselblatt, Hanna, Kurzbauer, Robert, Wilken, Corinna, Krojer, Tobias, Sawa, Justyna, Kurt, Juliane, Kirk, Rebecca, Hasenbein, Sonja, Ehrmann, Michael, Clausen, Tim
Publicado em 2007

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16

Por Dixon-Clarke, Sarah E., Shehata, Saifeldin N., Krojer, Tobias, Sharpe, Timothy D., vonDelft, Frank, Sakamoto, Kei, Bullock, Alex N.
Publicado no Biochem J (2017)

The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination

Por Krojer, Tobias, Talon, Romain, Pearce, Nicholas, Collins, Patrick, Douangamath, Alice, Brandao-Neto, Jose, Dias, Alexandre, Marsden, Brian, von Delft, Frank
Publicado no Acta Crystallogr D Struct Biol (2017)

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

Por Carr, Simon M., Munro, Shonagh, Zalmas, Lykourgos-Panagiotis, Fedorov, Oleg, Johansson, Catrine, Krojer, Tobias, Sagum, Cari A., Bedford, Mark T., Oppermann, Udo, La Thangue, Nicholas B.
Publicado em 2014

Gentle, fast and effective crystal soaking by acoustic dispensing

Por Collins, Patrick M., Ng, Jia Tsing, Talon, Romain, Nekrosiute, Karolina, Krojer, Tobias, Douangamath, Alice, Brandao-Neto, Jose, Wright, Nathan, Pearce, Nicholas M., von Delft, Frank
Publicado no Acta Crystallogr D Struct Biol (2017)

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

Por Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Publicado no Nat Commun (2017)

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain

Por Cox, Oakley B., Krojer, Tobias, Collins, Patrick, Monteiro, Octovia, Talon, Romain, Bradley, Anthony, Fedorov, Oleg, Amin, Jahangir, Marsden, Brian D., Spencer, John, von Delft, Frank, Brennan, Paul E.
Publicado no Chem Sci (2016)

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Por Kochan, Grazyna, Krojer, Tobias, Harvey, David, Fischer, Roman, Chen, Liye, Vollmar, Melanie, von Delft, Frank, Kavanagh, Kathryn L., Brown, Matthew A., Bowness, Paul, Wordsworth, Paul, Kessler, Benedikt M., Oppermann, Udo
Publicado em 2011

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

Por England, Katherine S., Tumber, Anthony, Krojer, Tobias, Scozzafava, Giuseppe, Ng, Stanley S., Daniel, Michelle, Szykowska, Aleksandra, Che, KaHing, von Delft, Frank, Burgess-Brown, Nicola A., Kawamura, Akane, Schofield, Christopher J., Brennan, Paul E.
Publicado no Medchemcomm (2014)

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

Por Gebel, Jakob, Luh, Laura M, Coutandin, Daniel, Osterburg, Christian, Löhr, Frank, Schäfer, Birgit, Frombach, Ann-Sophie, Sumyk, Manuela, Buchner, Lena, Krojer, Tobias, Salah, Eidarus, Mathea, Sebastian, Güntert, Peter, Knapp, Stefan, Dötsch, Volker
Publicado no Cell Death Differ (2016)

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Por Canning, Peter, Cooper, Christopher D. O., Krojer, Tobias, Murray, James W., Pike, Ashley C. W., Chaikuad, Apirat, Keates, Tracy, Thangaratnarajah, Chancievan, Hojzan, Viktorija, Marsden, Brian D., Gileadi, Opher, Knapp, Stefan, von Delft, Frank, Bullock, Alex N.
Publicado em 2013