Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Cullin-RING ligases are multisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single mu...

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Bibliographic Details
Main Authors: Canning, Peter, Cooper, Christopher D. O., Krojer, Tobias, Murray, James W., Pike, Ashley C. W., Chaikuad, Apirat, Keates, Tracy, Thangaratnarajah, Chancievan, Hojzan, Viktorija, Marsden, Brian D., Gileadi, Opher, Knapp, Stefan, von Delft, Frank, Bullock, Alex N.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597819/
https://ncbi.nlm.nih.gov/pubmed/23349464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437996
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