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Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension

Bone morphogenetic proteins (BMPs) are secreted ligands of the transforming growth factor-β (TGF-β) family that control embryonic patterning, as well as tissue development and homeostasis. Loss of function mutations in the type II BMP receptor BMPR2 are the leading cause of pulmonary arterial hypert...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chaikuad, Apirat, Thangaratnarajah, Chancievan, von Delft, Frank, Bullock, Alex N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892941/
https://ncbi.nlm.nih.gov/pubmed/31797984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54830-7
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