Proper modelling of ligand binding requires an ensemble of bound and unbound states

Autor Pearce, Nicholas M., Krojer, Tobias, von Delft, Frank
Vydáno v Acta Crystallogr D Struct Biol (2017)

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Autor van den Bos, Ramon M., Pearce, Nicholas M., Granneman, Joke, Brondijk, T. Harma C., Gros, Piet
Vydáno v Front Immunol (2019)

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

Autor Pearce, Nicholas M., Bradley, Anthony R., Krojer, Tobias, Marsden, Brian D., Deane, Charlotte M., von Delft, Frank
Vydáno v Struct Dyn (2017)

Gentle, fast and effective crystal soaking by acoustic dispensing

Autor Collins, Patrick M., Ng, Jia Tsing, Talon, Romain, Nekrosiute, Karolina, Krojer, Tobias, Douangamath, Alice, Brandao-Neto, Jose, Wright, Nathan, Pearce, Nicholas M., von Delft, Frank
Vydáno v Acta Crystallogr D Struct Biol (2017)

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Autor Keedy, Daniel A, Hill, Zachary B, Biel, Justin T, Kang, Emily, Rettenmaier, T Justin, Brandão-Neto, José, Pearce, Nicholas M, von Delft, Frank, Wells, James A, Fraser, James S
Vydáno v eLife (2018)

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

Autor Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Vydáno v Nat Commun (2017)

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

Autor Oosterheert, Wout, Xenaki, Katerina T, Neviani, Viviana, Pos, Wouter, Doulkeridou, Sofia, Manshande, Jip, Pearce, Nicholas M, Kroon-Batenburg, Loes MJ, Lutz, Martin, van Bergen en Henegouwen, Paul MP, Gros, Piet
Vydáno v Life Sci Alliance (2020)

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

Autor Wendt, Mathias, Bellavita, Rosa, Gerber, Alan, Efrém, Nina‐Louisa, van Ramshorst, Thirza, Pearce, Nicholas M., Davey, Paul R. J., Everard, Isabel, Vazquez‐Chantada, Mercedes, Chiarparin, Elisabetta, Grieco, Paolo, Hennig, Sven, Grossmann, Tom N.
Vydáno v Angew Chem Int Ed Engl (2021)