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A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

In macromolecular crystallography, the rigorous detection of changed states (for example, ligand binding) is difficult unless signal is strong. Ambiguous (‘weak' or ‘noisy') density is experimentally common, since molecular states are generally only fractionally present in the crystal. Exi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413968/
https://ncbi.nlm.nih.gov/pubmed/28436492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15123
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