Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Endoplasmatic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in trimming of peptides to an optimal length for presentation by major histocompatibility complex (MHC) class I molecules. Polymorphisms in ERAP1 have been associated with chronic inflammatory diseases, including a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kochan, Grazyna, Krojer, Tobias, Harvey, David, Fischer, Roman, Chen, Liye, Vollmar, Melanie, von Delft, Frank, Kavanagh, Kathryn L., Brown, Matthew A., Bowness, Paul, Wordsworth, Paul, Kessler, Benedikt M., Oppermann, Udo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093473/
https://ncbi.nlm.nih.gov/pubmed/21508329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101262108
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