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Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance

CD8(+) T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate CD8(+) T cell responses. Moreover, the T cell responses that are generated often follow a very rep...

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Detalles Bibliográficos
Autores principales: York, Ian A., Brehm, Michael A., Zendzian, Sophia, Towne, Charles F., Rock, Kenneth L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482590/
https://ncbi.nlm.nih.gov/pubmed/16754858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603095103
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