Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behçet's disease (BD). Previous studies have defined two subgroups of HLA-B*51 peptidome containing proline (Pro) or alanine (Ala) at position 2 (P2). Little is know...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Chen, Liye, Shi, Hui, Koftori, Danai, Sekine, Takuya, Nicastri, Annalisa, Ternette, Nicola, Bowness, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196583/
https://ncbi.nlm.nih.gov/pubmed/32161166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001617
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