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Regulation of the σE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

The unfolded protein response of Escherichia coli is triggered by the accumulation of unassembled outer membrane proteins (OMPs) in the cellular envelope. The PDZ-protease DegS recognizes these mislocalized OMPs and initiates a proteolytic cascade that ultimately leads to the σE-driven expression of...

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Detalhes bibliográficos
Main Authors: Hasselblatt, Hanna, Kurzbauer, Robert, Wilken, Corinna, Krojer, Tobias, Sawa, Justyna, Kurt, Juliane, Kirk, Rebecca, Hasenbein, Sonja, Ehrmann, Michael, Clausen, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000328/
https://ncbi.nlm.nih.gov/pubmed/17938245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.445307
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