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A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase

[Image: see text] Biosynthesis of 6-deoxy sugars, including l-fucose, involves a mechanistically complex, enzymatic 4,6-dehydration of hexose nucleotide precursors as the first committed step. Here, we determined pre- and postcatalytic complex structures of the human GDP-mannose 4,6-dehydratase at a...

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Publicat a:ACS Catal
Autors principals: Pfeiffer, Martin, Johansson, Catrine, Krojer, Tobias, Kavanagh, Kathryn L, Oppermann, Udo, Nidetzky, Bernd
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454399/
https://ncbi.nlm.nih.gov/pubmed/30984471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b00064
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