Mutation of GDP-Mannose-4,6-Dehydratase in Colorectal Cancer Metastasis

Fucosylation is a crucial oligosaccharide modification in cancer. The known function of fucosylation in cancer is to mediate metastasis through selectin ligand-dependent processes. Previously, we found complete loss of fucosylation in the colon cancer cell line HCT116 due to a mutation in the GDP-fu...

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Autores principales: Nakayama, Kotarosumitomo, Moriwaki, Kenta, Imai, Taku, Shinzaki, Shinichiro, Kamada, Yoshihiro, Murata, Kohei, Miyoshi, Eiji
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726606/
https://ncbi.nlm.nih.gov/pubmed/23922970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070298
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