Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-α subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for...

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Detalhes bibliográficos
Main Authors: McDonough, Michael A., Li, Vivian, Flashman, Emily, Chowdhury, Rasheduzzaman, Mohr, Christopher, Liénard, Benoît M. R., Zondlo, James, Oldham, Neil J., Clifton, Ian J., Lewis, Jeffrey, McNeill, Luke A., Kurzeja, Robert J. M., Hewitson, Kirsty S., Yang, Evelyn, Jordan, Steven, Syed, Rashid S., Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502536/
https://ncbi.nlm.nih.gov/pubmed/16782814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601283103
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