Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-α subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for...

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書誌詳細
主要な著者: McDonough, Michael A., Li, Vivian, Flashman, Emily, Chowdhury, Rasheduzzaman, Mohr, Christopher, Liénard, Benoît M. R., Zondlo, James, Oldham, Neil J., Clifton, Ian J., Lewis, Jeffrey, McNeill, Luke A., Kurzeja, Robert J. M., Hewitson, Kirsty S., Yang, Evelyn, Jordan, Steven, Syed, Rashid S., Schofield, Christopher J.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2006
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502536/
https://ncbi.nlm.nih.gov/pubmed/16782814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601283103
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