Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.

During biosynthesis of the clinically used beta-lactamase inhibitor clavulanic acid, one of the three steps catalysed by clavaminic acid synthase is separated from the other two by a step catalysed by proclavaminic acid amidino hydrolase (PAH), in which the guanidino group of an intermediate is hydr...

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Detalhes bibliográficos
Main Authors: Elkins, Jonathan M, Clifton, Ian J, Hernández, Helena, Doan, Linh X, Robinson, Carol V, Schofield, Christopher J, Hewitson, Kirsty S
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222790/
https://ncbi.nlm.nih.gov/pubmed/12020346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020125
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