Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Por Ehrismann, Dominic, Flashman, Emily, Genn, David N., Mathioudakis, Nicolas, Hewitson, Kirsty S., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado em 2006

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

Por McNeill, Luke A, Hewitson, Kirsty S, Claridge, Timothy D, Seibel, Jürgen F, Horsfall, Louise E, Schofield, Christopher J
Publicado em 2002

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.

Por Elkins, Jonathan M, Clifton, Ian J, Hernández, Helena, Doan, Linh X, Robinson, Carol V, Schofield, Christopher J, Hewitson, Kirsty S
Publicado em 2002

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

Por Hewitson, Kirsty S., Holmes, Samantha L., Ehrismann, Dominic, Hardy, Adam P., Chowdhury, Rasheduzzaman, Schofield, Christopher J., McDonough, Michael A.
Publicado em 2008

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

Por Lancaster, David E., McNeill, Luke A., McDONOUGH, Michael A., Aplin, Robin T., Hewitson, Kirsty S., Pugh, Christopher W., Ratcliffe, Peter J., Schofield, Christopher J.
Publicado em 2004

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Por Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.
Publicado em 2006

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

Por McDonough, Michael A., Li, Vivian, Flashman, Emily, Chowdhury, Rasheduzzaman, Mohr, Christopher, Liénard, Benoît M. R., Zondlo, James, Oldham, Neil J., Clifton, Ian J., Lewis, Jeffrey, McNeill, Luke A., Kurzeja, Robert J. M., Hewitson, Kirsty S., Yang, Evelyn, Jordan, Steven, Syed, Rashid S., Schofield, Christopher J.
Publicado em 2006

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase

Por Gerken, Thomas, Girard, Christophe A., Tung, Yi-Chun Loraine, Webby, Celia J., Saudek, Vladimir, Hewitson, Kirsty S., Yeo, Giles S. H., McDonough, Michael A., Cunliffe, Sharon, McNeill, Luke A., Galvanovskis, Juris, Rorsman, Patrik, Robins, Peter, Prieur, Xavier, Coll, Anthony P., Ma, Marcella, Jovanovic, Zorica, Farooqi, I. Sadaf, Sedgwick, Barbara, Barroso, Inês, Lindahl, Tomas, Ponting, Chris P., Ashcroft, Frances M., O'Rahilly, Stephen, Schofield, Christopher J.
Publicado em 2007