The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase

Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate–dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)-...

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Auteurs principaux: Gerken, Thomas, Girard, Christophe A., Tung, Yi-Chun Loraine, Webby, Celia J., Saudek, Vladimir, Hewitson, Kirsty S., Yeo, Giles S. H., McDonough, Michael A., Cunliffe, Sharon, McNeill, Luke A., Galvanovskis, Juris, Rorsman, Patrik, Robins, Peter, Prieur, Xavier, Coll, Anthony P., Ma, Marcella, Jovanovic, Zorica, Farooqi, I. Sadaf, Sedgwick, Barbara, Barroso, Inês, Lindahl, Tomas, Ponting, Chris P., Ashcroft, Frances M., O'Rahilly, Stephen, Schofield, Christopher J.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668859/
https://ncbi.nlm.nih.gov/pubmed/17991826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1151710
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