FTO is necessary for the induction of leptin resistance by high-fat feeding

OBJECTIVE: Loss of function FTO mutations significantly impact body composition in humans and mice, with Fto-deficient mice reported to resist the development of obesity in response to a high-fat diet (HFD). We aimed to further explore the interactions between FTO and HFD and determine if FTO can in...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Tung, Y.C. Loraine, Gulati, Pawan, Liu, Che-Hsiung, Rimmington, Debra, Dennis, Rowena, Ma, Marcella, Saudek, Vladimir, O'Rahilly, Stephen, Coll, Anthony P., Yeo, Giles S.H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354923/
https://ncbi.nlm.nih.gov/pubmed/25830092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.01.011
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