Role for the obesity-related FTO gene in the cellular sensing of amino acids

SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in s...

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Main Authors: Gulati, Pawan, Cheung, Man Ka, Antrobus, Robin, Church, Chris D., Harding, Heather P., Tung, Yi-Chun Loraine, Rimmington, Debra, Ma, Marcella, Ron, David, Lehner, Paul J., Ashcroft, Frances M., Cox, Roger D., Coll, Anthony P., O’Rahilly, Stephen, Yeo, Giles S. H.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574930/
https://ncbi.nlm.nih.gov/pubmed/23359686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222796110
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