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Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm
SNPs (single nucleotide polymorphisms) on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. FTO catalyses the Fe(II)- and 2OG-dependent demethylation of RNA and is an AA (amino acid) sensor that couples AA levels to mTORC1 (mammali...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Portland Press Ltd.
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4206862/ https://ncbi.nlm.nih.gov/pubmed/25242086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140111 |
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