Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm

SNPs (single nucleotide polymorphisms) on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. FTO catalyses the Fe(II)- and 2OG-dependent demethylation of RNA and is an AA (amino acid) sensor that couples AA levels to mTORC1 (mammali...

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Main Authors: Gulati, Pawan, Avezov, Edward, Ma, Marcella, Antrobus, Robin, Lehner, Paul, O’Rahilly, Stephen, Yeo, Giles S. H.
格式: Artigo
語言:Inglês
出版: Portland Press Ltd. 2014
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Original Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206862/
https://ncbi.nlm.nih.gov/pubmed/25242086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140111
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