Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

The strongest BMI–associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alteration...

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書誌詳細
主要な著者: McMurray, Fiona, Church, Chris D., Larder, Rachel, Nicholson, George, Wells, Sara, Teboul, Lydia, Tung, Y. C. Loraine, Rimmington, Debra, Bosch, Fatima, Jimenez, Veronica, Yeo, Giles S. H., O'Rahilly, Stephen, Ashcroft, Frances M., Coll, Anthony P., Cox, Roger D.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536712/
https://ncbi.nlm.nih.gov/pubmed/23300482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003166
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