Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

The strongest BMI–associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alteration...

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Autores principales: McMurray, Fiona, Church, Chris D., Larder, Rachel, Nicholson, George, Wells, Sara, Teboul, Lydia, Tung, Y. C. Loraine, Rimmington, Debra, Bosch, Fatima, Jimenez, Veronica, Yeo, Giles S. H., O'Rahilly, Stephen, Ashcroft, Frances M., Coll, Anthony P., Cox, Roger D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536712/
https://ncbi.nlm.nih.gov/pubmed/23300482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003166
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