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Overexpression of Fto leads to increased food intake and results in obesity
Genome-wide association studies have identified SNPs within the human FTO gene that display a strong association with obesity. Individuals homozygous for the at-risk rs9939609 A allele weigh ~3kg more. Loss of function and/or expression of FTO in mice leads to increased energy expenditure and a lean...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018646/ https://ncbi.nlm.nih.gov/pubmed/21076408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.713 |
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