Overexpression of Fto leads to increased food intake and results in obesity

Genome-wide association studies have identified SNPs within the human FTO gene that display a strong association with obesity. Individuals homozygous for the at-risk rs9939609 A allele weigh ~3kg more. Loss of function and/or expression of FTO in mice leads to increased energy expenditure and a lean...

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Bibliografiska uppgifter
Huvudupphovsmän: Church, Chris, Moir, Lee, McMurray, Fiona, Girard, Christophe, Banks, Gareth T, Teboul, Lydia, Wells, Sara, Bruning, Jens C., Nolan, Patrick M, Ashcroft, Frances M., Cox, Roger D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018646/
https://ncbi.nlm.nih.gov/pubmed/21076408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.713
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