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Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway

Sustained hypoxic exposure increases ventilatory sensitivity to hypoxia as part of physiological acclimatisation. Oxygen‐sensitive signals are transduced in animal cells by post‐translational hydroxylation of transcription factors termed hypoxia‐inducible factors (HIFs). Mice heterozygous for the pr...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Hodson, Emma J., Nicholls, Lynn G., Turner, Philip J., Llyr, Ronan, Fielding, James W., Douglas, Gillian, Ratnayaka, Indrika, Robbins, Peter A., Pugh, Christopher W., Buckler, Keith J., Ratcliffe, Peter J., Bishop, Tammie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771794/
https://ncbi.nlm.nih.gov/pubmed/26337139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271050
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